Description: Basic understanding of Biochemistry, Cell and Molecular Biology is prerequisite for this course offered to students in the final year of their degree program. This is designed to provide a comprehensive overview of the Chemistry, Biology and Pathology of cancer. Students opting for this course will be considered of having a specialization in modern cancer biology and therapeutics. The course is divided into two broad parts. The first part will focus on the genetic and molecular basis of cancer, while the second half will discuss the interface between cancer and medicine. The students will also be introduced to the concepts of anti-cancer drug resistance and the ever-growing need to implement personalized anti-cancer therapeutics in clinic. The use of genomics, proteomics and metabolomics tools for identification of diagnostics, predictive and prognostic cancer biomarkers will be presented. Pharmaceutical approach of anti-cancer drug discovery and concepts of clinical trials will also be discussed. Biology: Definition and pathology of cancer. Cancer is a slow growing disease. War against cancer. Cancer is a multistep process: evolution of cancer. Eight hallmarks of cancer. Inflammation and genomic instability as causes of cancer. Carcinogens/mutagens. Tumor heterogeneity. Tumor suppressors, oncogenes/oncogene addiction theory. Cancer cell signaling: PI3K and MAPK signaling. Apoptosis, autophagy, senescence and their roles in cancer. Cancer stem cells
Therapeutics: Chemo, targeted, immuno and stem-cell therapies. Anti-cancer drug resistance. Biomarkers: Diagnostic, prognostic and predictive. Personalized therapies: concept, experimental tools. 2 Cancer Genomics. Functional genomics. Synthetic lethality. Clinical trials.